Improving the physicochemical properties and oral bioavailability of quetiapine fumarate (QF) enabling enhanced antipsychotic\nattributes are the main aims of this research. The freeze dried solid dispersion strategy was adopted using nicotinamide (NIC)\nas highly soluble coformer. The prepared dispersions were characterized using scanning electron microscopy (SEM) differential\nscanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). Static disc intrinsic\ndissolution rate and ex vivo diffusion through intestinal tissues were conducted and compared to pure quetiapine fumarate. The\nresults demonstrated a highly soluble coamorphous system formed between quetiapine fumarate and nicotinamide at 1 : 3 molar\nratio through H-bonding interactions. The results showed >14-fold increase in solubility of QF from the prepared dispersions.\nIncreased intrinsic dissolution rate (from 0.28 to 0.603mg cmâË?â??2 minâË?â??1) and faster flux rate through duodenum (from 0.027 to\n0.041mg cmâË?â??2 hâË?â??1) and jejunum (0.027 to 0.036mg cmâË?â??2 hâË?â??1) were obtained.The prepared coamorphous dispersion proved to be\neffective in improving the drug solubility and dissolution rate and ex vivo diffusion. Therefore, binary coamorphous dispersions\ncould be a promising solution tomodify the physicochemical properties, raise oral bioavailability, and change the biopharmaceutics\nclassification (BCS) of some active pharmaceutical ingredients.
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